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Exhibit 10.1

 

SECOND Amendment

to

Loan
and security agreement

 

This Second Amendment
to Loan and Security Agreement (this “Amendment”) is entered into this 28th day of August, 2020, by and between
SILICON VALLEY BANK (“Bank”) and MERSANA THERAPEUTICS, INC., a Delaware corporation (“Borrower”)
whose address is 840 Memorial Drive, Cambridge, Massachusetts 02139.

 

Recitals

 

A.       Bank
and Borrower have entered into that certain Loan and Security Agreement dated as of May 8, 2019, as amended by that certain First
Amendment to Loan and Security Agreement between Bank and Borrower dated as of June 21, 2019, (as the same may from time to time
be further amended, modified, supplemented or restated, the “Loan Agreement”).

 

B.       Bank
has extended credit to Borrower for the purposes permitted in the Loan Agreement.

 

C.       Borrower
has requested that Bank amend the Loan Agreement to (i) provide a new term loan, and (ii) make certain other revisions to
the Loan Agreement as more fully set forth herein.

 

D.       Bank
has agreed to so amend certain provisions of the Loan Agreement, but only to the extent, in accordance with the terms, subject
to the conditions and in reliance upon the representations and warranties set forth below.

 

Agreement

 

Now,
Therefore,
in consideration of the foregoing recitals and other good and valuable consideration, the receipt and adequacy
of which is hereby acknowledged, and intending to be legally bound, the parties hereto agree as follows:

 

1.                 
Definitions. Capitalized terms used
but not defined in this Amendment shall have the meanings given to them in the Loan Agreement.

 

2.                 
Amendments to Loan Agreement.

 

2.1             
Section 2.1.2 (2020 Term Loan Advances). The
Loan Agreement is amended by inserting the following new provision to appear as Section 2.1.2 (2020 Term Loan Advances) thereof:

 

 

2.1.2           2020 Term Loan
Advances
.

 

(a)       Availability.
Subject to the terms and conditions of this Agreement, upon Borrower’s request, during the 2020 Draw Period A, Bank
shall make up to five (5) term loan advances (each, a “2020 Term A Loan Advance”, and collectively, the
2020 Term A Loan Advances”) available to Borrower in an aggregate original principal amount not to exceed
Twenty Five Million Dollars ($25,000,000.00); provided that the initial 2020 Term A Loan Advance (which shall be in an amount
of at least Five Million Two Hundred Thousand Dollars ($5,200,000.00) (the “Initial 2020 Term A Loan
Advance
”) (i) shall be made on or about the Second Amendment Effective Date, and (ii) all or a portion of the
proceeds of the Initial 2020 Term A Loan Advance shall be used to repay in full Borrower’s outstanding obligations and
liabilities to Bank existing as of the Second Amendment Effective Date, which shall include the Final Payment (but shall not
include the Unused Term Loan Commitment Fee, the Prepayment Fee, or the Waived Final Payment, which are waived by Bank as of
the Second Amendment Effective Date) (the “Prior Obligations”). Borrower hereby authorizes Bank to apply
the proceeds of the Initial 2020 Term A Loan Advance to the Prior Obligations as part of the funding process without actually
depositing such funds into an account of Borrower. Upon the application of the Initial 2020 Term A Loan Advance to the Prior
Obligations, the Prior Obligations will be paid in full. Subject to the terms and conditions of this Agreement, upon
Borrower’s request, during the 2020 Draw Period B, Bank shall make one (1) term loan advance (the “2020 Term B
Loan Advance
”) available to Borrower in an original principal amount of Five Million Dollars ($5,000,000.00). The
2020 Term A Loan Advances and the 2020 Term B Loan Advance are each hereinafter referred to singly as a “2020 Term
Loan Advance
” and collectively as the “2020 Term Loan Advances”. After repayment, no 2020 Term
Loan Advance (or any portion thereof) may be reborrowed. For the avoidance of doubt, upon the repayment of the Prior
Obligations, no further Term Loan Advances are available.

 

(b)       Interest
Period.
Commencing on the first (1st) Payment Date of the month following the month in which the Funding Date of the applicable
2020 Term Loan Advance occurs, and continuing on each Payment Date thereafter, Borrower shall make monthly payments of interest
on the principal amount of each 2020 Term Loan Advance at the rate set forth in Section 2.2(a)(ii).

 

(c)       Repayment.
Commencing on the 2020 Term Loan Amortization Date, and continuing on each Payment Date thereafter, Borrower shall repay each 2020
Term Loan Advance in (i) consecutive equal monthly installments of principal according to the 2020 Repayment Schedule, plus (ii)
monthly payments of accrued interest at the rate set forth in Section 2.2(a)(ii). All outstanding principal and accrued and unpaid
interest with respect to the 2020 Term Loan Advances, and all other outstanding Obligations with respect to the 2020 Term Loan
Advances, are due and payable in full on the 2020 Term Loan Maturity Date.

 

(d)       Mandatory
Prepayment Upon an Acceleration
. If the 2020 Term Loan Advances are accelerated following the occurrence of an Event of Default,
Borrower shall immediately pay to Bank an amount equal to the sum of: (i) all outstanding principal plus accrued and unpaid interest,
(ii) the 2020 Final Payment, (iii) the 2020 Prepayment Fee, plus (iv) all other sums, if any, that shall have become due and payable,
including interest at the Default Rate with respect to any past due amounts.

 

(e)       Permitted
Prepayment of 2020 Term Loan Advances
. Borrower shall have the option to prepay all, but not less than all, of the 2020 Term
Loan Advances advanced by Bank under this Agreement, provided Borrower (i) provides written notice to Bank of its election to prepay
the 2020 Term Loan Advances at least ten (10) days prior to such prepayment, and (ii) pays, on the date of such prepayment (A)
all outstanding principal plus accrued and unpaid interest, (B) the 2020 Final Payment, (C) the 2020 Prepayment Fee, plus (D) all
other sums, if any, that shall have become due and payable, including interest at the Default Rate with respect to any past due
amounts.”

 

 

2.2         
Section 2.2 (Payment of Interest on the Credit Extensions).
Section 2.2(a) is amended in its entirety and replaced with the following:

 

“              (a)          Interest Rate.

 

(i)       Subject
to Section 2.2(b), the principal amount outstanding for each Term Loan Advance shall accrue interest at a floating per annum rate
equal to the greater of (i) four percent (4.0%) and (ii) one and one-half of one percent (1.50%) below the Prime Rate, which interest,
in each case, shall be payable monthly in accordance with Section 2.2(d) below.

 

(ii)       Subject
to Section 2.2(b), the principal amount outstanding for each 2020 Term Loan Advance shall accrue interest at a floating per annum
rate equal to the greater of (i) one percent (1.00%) above the Prime Rate, and (ii) four and one-quarter of one percent (4.25%),
and which interest, in each case, shall be payable monthly in accordance with Section 2.2(d) below.”

 

2.3         
Section 2.3 (Fees). Section 2.3 is amended
by (i) deleting the text “and” appearing at the end of subsection (e) thereof; (ii) re-lettering subsection (f) to
appear as subsection (i) thereof, and (iii) inserting the following new subsections (f), (g), and (h) thereof:

 

“              (f)            2020 Final Payment. The 2020
Final Payment, when due hereunder;

 

(g)           2020
Prepayment Fee
. The 2020 Prepayment Fee, if and when due hereunder;

 

(h)       
   2020 Good Faith Deposit. Borrower has paid to Bank a deposit of Thirty Thousand Dollars ($30,000.00)
(the “2020 Good Faith Deposit”), to initiate Bank’s due diligence review process. The 2020 Good
Faith Deposit shall be utilized toward the payment of Bank Expenses on the Second Amendment Effective Date; and”

 

2.4          
Section 6.2 (Financial Statements, Reports, Certificates).
Section 6.2(b) is amended in its entirety and replaced with the following:

 

“              (b)          Monthly
Compliance Certificate
. Within thirty (30) days after the last day of each month, a duly completed Compliance Certificate
signed by a Responsible Officer, certifying that as of the end of such month, Borrower was in full compliance with all of the
terms and conditions of this Agreement, and setting forth calculations showing compliance with the financial covenants (if any)
set forth in this Agreement and such other information as Bank may reasonably request;”

 

2.5         
Section 6.6 (Operating Accounts). The first
two sentences of Section 6.6(a) are amended in their entirety and replaced with the following:

 

“              (a)           Maintain all
of its and all of its Subsidiaries’ (excluding Securities Corp.) operating accounts and all excess cash with Bank and Bank’s
Affiliates. In addition to the foregoing, Borrower shall at all times have on deposit in operating accounts maintained in the name
of Borrower with Bank, cash in an amount equal to the lesser of (i) one hundred percent (100.0%) of the Dollar value of Borrower’s
consolidated cash, including any Subsidiaries’, Affiliates’, or related entities’ cash, in the aggregate, at
all financial institutions, and (ii) one hundred five percent (105.0%) of the then-outstanding Obligations of Borrower to Bank.”

 

2.6         
Section 6.7 (Financial Covenant – Liquidity Ratio).
Section 6.7 is amended in its entirety and replaced with the following:

 

6.7        Reserved.”

 

 

2.7         
Section 7.1 (Dispositions). Section 7.1 of
the Loan Agreement is amended by inserting the words “(including, without limitation, pursuant to a Division)” to appear
immediately prior to the words “(collectively, “Transfer”)”.

 

2.8         
Section 7.3 (Mergers or Acquisitions). Section
7.3 of the Loan Agreement is amended in its entirety and replaced with the following:

 

7.3         Mergers or Acquisitions.
Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with any other Person, or acquire, or permit any
of its Subsidiaries to acquire, all or substantially all of the capital stock or property of another Person (including, without
limitation, by the formation of any Subsidiary or pursuant to a Division). A Subsidiary may merge or consolidate into another Subsidiary
or into Borrower.”

 

2.9         
Section 8.1 (Payment Default). Section 8.1
is amended by replacing the words “Term Loan Maturity Date” with “Maturity Date”.

 

2.10       
Section 12.1 (Termination Prior to Maturity Date; Survival).
Section 12.1 is amended by replacing the words “Term Loan Maturity Date” with “Maturity Date”.

 

2.11       
Section 13.1 (Definitions). The following
terms and their respective definitions set forth in Section 13.1 are amended in their entirety and replaced with the following:

 

“              “Credit Extension
is any Term Loan Advance, any 2020 Term Loan Advance, or any other extension of credit by Bank for Borrower’s benefit.”

 

“              “Obligations
are Borrower’s obligations to pay when due any debts, principal, interest, fees, Bank Expenses, the Unused Term Loan Commitment
Fee, the Prepayment Fee, the Final Payment, the 2020 Final Payment, the 2020 Prepayment Fee, and other amounts Borrower owes Bank
now or later, whether under this Agreement, the other Loan Documents, or otherwise, including, without limitation, all obligations
relating to Bank Services and any interest accruing after Insolvency Proceedings begin and debts, liabilities, or obligations of
Borrower assigned to Bank, and to perform Borrower’s duties under the Loan Documents.”

 

“              “Term Loan
Maturity Date
” is the Second Amendment Effective Date.”

 

2.12       
Section 13.1 (Definitions). The Loan Agreement
is amended by inserting the following new terms and their respective definitions to appear alphabetically in Section 13.1 thereof:

 

“              “2020 Draw
Period A
” is the period of time commencing on the Second Amendment Effective Date, and continuing through the earlier
to occur of (a) April 30, 2022, or (b) an Event of Default.

 

“              “2020 Draw
Period B
” is the period of time commencing upon the occurrence of the 2020 IND Event, and continuing through the earlier
to occur of (i) April 30, 2022, or (ii) an Event of Default.”

 

 

“              “2020 Final
Paymen
t” is a payment (in addition to and not in substitution for the regular monthly payments of principal plus accrued
interest) equal to the original principal amount of the 2020 Term Loan Advances extended by Bank to Borrower hereunder multiplied
by five and one-half of one percent (5.5%), due on the earliest to occur of (a) the 2020 Term Loan Maturity Date, (b) the payment
in full of such 2020 Term Loan Advances, (c) as required by Section 2.1.2(d) or Section 2.1.2(e), or (d) the termination of this
Agreement.”

 

“              “2020 Good
Faith Deposit
” is defined in Section 2.3(h).”

 

“              “2020 Interest
Only Extension Event
” occurs if and when (if ever) Bank confirms in writing that it has received evidence, on or prior
to May 31, 2022, satisfactory to Bank in its sole and absolute discretion, that Borrower has received sufficient data, on or prior
to May 31, 2022, to submit a Biologics License Application for XMT 1536 to the FDA.”

 

“              “2020 IND
Event
” occurs if and when (if ever) Bank confirms in writing that it has received evidence, on or prior to April 30,
2022, satisfactory to Bank in Bank’s sole and absolute discretion, that (i) Borrower has submitted an IND to the FDA for
a third (3rd) clinical asset and the FDA has not made any objections within thirty (30) days of Borrower filing such IND application
with the FDA on prior to April 30, 2022, or (ii) Borrower has submitted an IND to the FDA for a third (3rd) clinical asset and
the FDA has provided clearance in writing (satisfactory to Bank in its sole and absolute discretion) to proceed to a human clinical
trial under such IND on prior to April 30, 2022.”

 

“              “2020 Prepayment
Fee
” shall be an additional fee, payable to Bank, with respect to the 2020 Term Loan Advances, in an amount equal to:

 

(a)       for
a prepayment of the 2020 Term Loan Advances made on or prior to the first (1st) anniversary of the Second Amendment
Effective Date, three percent (3.0%) of the then outstanding principal amount of the 2020 Term Loan Advances immediately prior
to the date of such prepayment;

 

(b)       for
a prepayment of the 2020 Term Loan Advances made after the first (1st) anniversary of the Second Amendment Effective
Date, but on or prior to the second (2nd) anniversary of the Second Amendment Effective Date, two percent (2.0%) of
the then outstanding principal amount of the 2020 Term Loan Advances immediately prior to the date of such prepayment; and

 

(c)       for
a prepayment of the 2020 Term Loan Advances made after the second (2nd) anniversary of the Second Amendment Effective
Date, but before the 2020 Term Loan Maturity Date, one percent (1.0%) of the then outstanding principal amount of the 2020 Term
Loan Advances immediately prior to the date of such prepayment.

 

Notwithstanding
the foregoing, provided no Event of Default has occurred and is continuing, the 2020 Prepayment Fee shall be waived by Bank if
Bank closes on the refinance and redocumentation of the 2020 Term Loan Advances (in its sole and absolute discretion) prior to
the 2020 Term Loan Maturity Date.”

 

 

“              “2020 Repayment
Schedule
” means the period of time equal to thirty (30) consecutive calendar months, which shall be reduced to twenty-two
(22) consecutive calendar months upon the occurrence of the 2020 Interest Only Extension Event.”

 

“              “2020 Term
A Loan Advance
” and “2020 Term A Loan Advances” are each defined in Section 2.1.2(a).”

 

“              “2020 Term
B Loan Advance
” is defined in Section 2.1.2(a).”

 

“              “2020 Term
Loan Advance
” and “2020 Term Loan Advances” are each defined in Section 2.1.2(a).”

 

“              “2020 Term
Loan Amortization Date
” is June 1, 2022, which shall be extended to February 1, 2023, upon the occurrence of the 2020
Interest Only Extension Event.”

 

“              “2020 Term
Loan Maturity Date
” is November 1, 2024.”

 

“              “Biologics
License Application
” means an application for licensure of a biological product submitted to the FDA under 42 U.S.C.
§ 262(k) for permission to introduce, or deliver for introduction, a biologic product into interstate commerce.”

 

“              “Division
means, in reference to any Person which is an entity, the division of such Person into two (2) or more separate Persons, with the
dividing Person either continuing or terminating its existence as part of such division, including, without limitation, as contemplated
under Section 18-217 of the Delaware Limited Liability Company Act for limited liability companies formed under Delaware law, or
any analogous action taken pursuant to any other applicable law with respect to any corporation, limited liability company, partnership
or other entity.”

 

“              “FDA
means the U.S. Food and Drug Administration or any successor thereto.”

 

“              “IND
means an investigational new drug application submitted to the FDA pursuant to 21 C.F.R. § 312 (or its successor regulation)
requesting authorization to initiate clinical trials in human subjects.”

 

“              “Initial 2020
Term A Loan Advance
” is defined in Section 2.1.2(a).”

 

“              “Maturity Date
means the Term Loan Maturity Date and the 2020 Term Loan Maturity Date, as applicable.”

 

“              “Prior Obligations
is defined in Section 2.1.2(a).”

 

“              “Second Amendment
Effective Date
” is August 28, 2020.”

 

“              “Waived Final
Payment
” is the unaccrued portion of the Final Payment, which shall be an amount equal to Fifty Thousand Dollars ($50,000.00).”

 

2.13        
Exhibit B (Compliance Certificate).
The Compliance Certificate is amended in its entirety and replaced with the Compliance Certificate in the form of Schedule 1
attached hereto.

 

 

3.                 
Limitation of Amendments.

 

3.1             
The amendments set forth in Section 2 above are effective for the purposes set forth
herein and shall be limited precisely as written and shall not be deemed to (a) be a consent to any amendment, waiver or modification
of any other term or condition of any Loan Document, or (b) otherwise prejudice any right or remedy which Bank may now have
or may have in the future under or in connection with any Loan Document.

 

3.2             
This Amendment shall be construed in connection with and as part of the Loan Documents
and all terms, conditions, representations, warranties, covenants and agreements set forth in the Loan Documents, except as herein
amended, are hereby ratified and confirmed and shall remain in full force and effect.

 

4.              
Representations and Warranties. To
induce Bank to enter into this Amendment, Borrower hereby represents and warrants to Bank as follows:

 

4.1             
Immediately after giving effect to this Amendment (a) the representations and warranties
contained in the Loan Documents are true, accurate and complete in all material respects as of the date hereof (except to the extent
such representations and warranties relate to an earlier date, in which case they are true and correct as of such date), and (b) no
Event of Default has occurred and is continuing;

 

4.2             
Borrower has the power and authority to execute and deliver this Amendment and to perform
its obligations under the Loan Agreement, as amended by this Amendment;

 

4.3             
The organizational documents of Borrower delivered to Bank on the Effective Date remain
true, accurate and complete and have not been amended, supplemented or restated and are and continue to be in full force and effect;

 

4.4             
The execution and delivery by Borrower of this Amendment and the performance by Borrower
of its obligations under the Loan Agreement, as amended by this Amendment, have been duly authorized;

 

4.5             
The execution and delivery by Borrower of this Amendment and the performance by Borrower
of its obligations under the Loan Agreement, as amended by this Amendment, do not and will not contravene (a) any law or regulation
binding on or affecting Borrower, (b) any contractual restriction with a Person binding on Borrower, (c) any order, judgment
or decree of any court or other governmental or public body or authority, or subdivision thereof, binding on Borrower, or (d) the
organizational documents of Borrower;

 

4.6             
The execution and delivery by Borrower of this Amendment and the performance by Borrower
of its obligations under the Loan Agreement, as amended by this Amendment, do not require any order, consent, approval, license,
authorization or validation of, or filing, recording or registration with, or exemption by any governmental or public body or authority,
or subdivision thereof, binding on Borrower, except as already has been obtained or made; and

 

4.7             
This Amendment has been duly executed and delivered by Borrower and is the binding obligation
of Borrower, enforceable against Borrower in accordance with its terms, except as such enforceability may be limited by bankruptcy,
insolvency, reorganization, liquidation, moratorium or other similar laws of general application and equitable principles relating
to or affecting creditors’ rights.

 

 

5.                  Updated
Perfection Certificate.
 Borrower has delivered an updated Perfection
Certificate in connection with this Amendment (the “Updated Perfection Certificate”) dated as of the
date
hereof, which Updated Perfection Certificate shall supersede in all respects that certain Perfection
Certificate dated as of May 8, 2019. Borrower agrees that all references in the Loan Agreement to “Perfection
Certificate” shall hereinafter be deemed to be a reference to the Updated Perfection Certificate.

 

6.                 
Ratification of Stock Pledge Agreement.
Borrower hereby ratifies, confirms and reaffirms, all and singular, the terms and conditions of a certain Stock Pledge Agreement dated
as of May 8, 2019 between Borrower and Bank, and acknowledges, confirms and agrees that said Stock Pledge Agreement shall
remain in full force and effect.

 

7.                 
Integration. This Amendment and the
Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements. All prior
agreements, understandings, representations, warranties, and negotiations between the parties about the subject matter of this
Amendment and the Loan Documents merge into this Amendment and the Loan Documents.

 

8.                 
Counterparts. This Amendment may be
executed in any number of counterparts and all of such counterparts taken together shall be deemed to constitute one and the same
instrument.

 

9.                 
Effectiveness. This Amendment shall
be deemed effective upon (a) the due execution and delivery to Bank of this Amendment by each party hereto, and (b) Borrower’s
payment of Bank’s legal fees and expenses incurred in connection with this Amendment.

 

[Signature page follows.]

 

 

In
Witness Whereof,
the parties hereto have caused this Amendment to be duly executed and delivered as of the date first
written above.

 

BANK BORROWER
   
SILICON VALLEY BANK MERSANA THERAPEUTICS, INC.
         
By: /s/ Dan Greaney   By: /s/ Brian DeSchuytner
Name:   Dan Greaney Name:  Brian DeSchuytner
Title: Vice President Title: Senior Vice President, Finance and Product Strategy

 

 

SCHEDULE 1

 

EXHIBIT B

 

COMPLIANCE CERTIFICATE

 

TO: SILICON VALLEY BANK Date:    

FROM:   MERSANA THERAPEUTICS,
INC.

 

The undersigned authorized
officer of MERSANA THERAPEUTICS, INC. (“Borrower”) certifies that under
the terms and conditions of the Loan and Security Agreement between Borrower and Bank (the “Agreement”):

 

(1) Borrower is
in complete compliance for the period ending _______________ with all required covenants except as noted below; (2) there
are no Events of Default; (3) all representations and warranties in the Agreement are true and correct in all material respects
on this date except as noted below; provided, however, that such materiality qualifier shall not be applicable to any representations
and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations
and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such
date; (4) Borrower, and each of its Subsidiaries, has timely filed all required tax returns and reports, and Borrower has
timely paid all foreign, federal, state and local taxes, assessments, deposits and contributions owed by Borrower except as otherwise
permitted pursuant to the terms of Section 5.8 of the Agreement; and (5) no Liens have been levied or claims made against
Borrower or any of its Subsidiaries relating to unpaid employee payroll or benefits of which Borrower has not previously provided
written notification to Bank.

 

Attached are the required
documents supporting the certification. The undersigned certifies that these are prepared in accordance with GAAP consistently
applied from one period to the next except as explained in an accompanying letter or footnotes. The undersigned acknowledges that
no borrowings may be requested at any time or date of determination that Borrower is not in compliance with any of the terms of
the Agreement, and that compliance is determined not just at the date this certificate is delivered. Capitalized terms used but
not otherwise defined herein shall have the meanings given them in the Agreement.

 

Please indicate
compliance status by circling Yes/No under “Complies” column.

 

Reporting Covenants Required Complies
10-Q Report Within 45 days of quarter end  
Compliance Certificate Monthly within 30 days Yes   No
Board projections At least annually, FYE within 60 days and contemporaneously with any updates or changes thereto Yes   No
10-K Report and annual audited financial statement FYE within 90 days Yes   No
Filed Proxy, 10-Q, 10-K and 8-K Within 5 days after filing with SEC Yes   No

 

Other Matters

 

Have there been any amendments of or other changes to the capitalization table of Borrower and to the Operating Documents of Borrower or any of its Subsidiaries?  If yes, provide copies of any such amendments or changes with this Compliance Certificate. Yes No

 

The following are the exceptions with respect
to the certification above: (If no exceptions exist, state “No exceptions to note.”)

 

 

MERSANA THERAPEUTICS, INC. BANK USE ONLY

 

By:     Received by:  
Name:       AUTHORIZED
SIGNER
Title:     Date:  
         
        AUTHORIZED
SIGNER
      Date:  
         
  Compliance Status:      Yes       No

 

 



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