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SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

 

SCHEDULE 13D

(Rule 13d-102)

 

INFORMATION TO BE INCLUDED IN STATEMENTS
FILED PURSUANT

TO RULE 13d-l(a) AND AMENDMENTS THERETO
FILED PURSUANT

TO RULE 13d-2(a)

 

(Amendment No. 8)*

  

BeiGene,
Ltd.

(Name of Issuer)

 

Ordinary Shares, par value $0.0001 per
share
 

(Title of Class of Securities)

 

 

07725L102**

(CUSIP number)

 

Alexandra A. Toohey

Chief Financial Officer

Baker Bros. Advisors LP

860 Washington Street, 3rd Floor

New York, NY 10014

(212) 339-5690

(Name, address and telephone number
of person authorized to receive notices and communications)

 

December 1, 2020

(Date of event which requires filing
of this statement)

 

If
the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule
13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box. ¨

 

(Continued on the following pages)

 

(Page 1 of 10 Pages)

________________________________

*The remainder of this cover page shall
be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for
any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

 

The information required on the remainder of this cover page
shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise
subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.

**This CUSIP applies to the American Depositary Shares, each
representing thirteen Ordinary Shares

 

CUSIP No.  07725L102   Page   2   of   10   Pages

 

 

1.

NAMES OF REPORTING PERSONS

 

Baker Bros. Advisors LP 

2.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

(a)
¨

(b)
¨

3.

SEC USE ONLY

 

4.

SOURCE OF FUNDS*

 

OO

5.

CHECK
BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨

 

6.

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware

 NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

 REPORTING

PERSON WITH

7.

SOLE VOTING POWER:

 

153,853,343 (1)

8.

SHARED VOTING POWER:

 

0

9.

SOLE DISPOSITIVE POWER:

 

153,853,343 (1)

10.

SHARED DISPOSITIVE POWER:

 

0

11.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
PERSON:

 

153,853,343 (1)

12.

CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
¨

 

13.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(11)

 

13.0% (1)(2)

14.

TYPE OF REPORTING PERSON*

 

IA, PN

 

(1) Includes 153,270,663 of the Ordinary Shares (“Ordinary
Shares”) of BeiGene, Ltd. (the “Issuer”) reported that are beneficially owned through American Depositary Shares
(“ADS”), 18,564 Ordinary Shares received from vested restricted stock units of the Issuer (“RSU’s”)
and 564,070 Ordinary Shares underlying 564,070 options to purchase Ordinary Shares (“Share Options”). Each ADS represents
13 Ordinary Shares of the Issuer.
(2) Based on 1,182,083,060 Ordinary Shares outstanding
at November 30, 2020 as reported by the Issuer on the Hong Kong Exchange and Clearing Limited (“HKEX”) on November
30, 2020.

 

 CUSIP
No.  07725L102
  Page   3   of   10   Pages

 

 

1.

NAMES OF REPORTING PERSONS

 

Baker Bros. Advisors (GP) LLC 

2.

CHECK THE APPROPRIATE BOX IF A MEMBER
OF A GROUP*

(a)
¨

(b)
¨

3.

SEC USE ONLY

 

4.

SOURCE OF FUNDS*

 

OO

5.

CHECK
BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)
¨

 

6.

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware

 NUMBER

OF SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON WITH

7.

SOLE VOTING POWER:

 

153,853,343 (1)

8.

SHARED VOTING POWER:

 

0

9.

SOLE DISPOSITIVE POWER:

 

153,853,343 (1)

10.

SHARED DISPOSITIVE POWER:

 

0

11.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
PERSON:

 

153,853,343 (1)

12.

CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
¨

 

13.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(11)

 

13.0% (1)(2)

14.

TYPE OF REPORTING PERSON*

 

HC, OO

 

(1) Includes 153,270,663 of the Ordinary Shares reported
that are beneficially owned through ADS, 18,564 Ordinary Shares received from vested RSU’s and 564,070 Ordinary Shares underlying
564,070 Share Options. Each ADS represents 13 Ordinary Shares of the Issuer.
(2) Based on 1,182,083,060 Ordinary Shares outstanding
at November 30, 2020 as reported by the Issuer on the HKEX on November 30, 2020.

 

CUSIP
No. 07725L102
  Page   4   of   10  Pages

 

 

1.

 

NAMES OF REPORTING PERSONS

 

Felix J. Baker 

2.

 

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

(a)
¨

(b)
¨

3.

 

SEC USE ONLY

4.

 

SOURCE OF FUNDS*

 

OO 

5.

 

CHECK
BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)
¨

 

6.

 

CITIZENSHIP OR PLACE OF ORGANIZATION

 

United States 

 NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

7.

 

SOLE VOTING POWER:

 

154,315,490 (1)

8.

 

SHARED VOTING POWER:

 

 

9.

 

SOLE DISPOSITIVE POWER:

 

154,315,490 (1) 

10.

 

SHARED DISPOSITIVE POWER:

 

 

11.

 

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
PERSON:

 

154,315,490 (1) 

12.

 

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
EXCLUDES CERTAIN SHARES* ¨

 

13.

 

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(11)

 

13.0% (1)(2) 

14.

 

TYPE OF REPORTING PERSON*

 

IN, HC

 

(1) Includes 153,270,663 Ordinary Shares reported that
are beneficially owned through ADS, 18,564 Ordinary Shares received from vested RSU’s, and 564,070 Ordinary Shares underlying
564,070 Share Options. Each ADS represents 13 Ordinary Shares of the Issuer.
(2) Based on 1,182,083,060 Ordinary Shares outstanding
at November 30, 2020 as reported by the Issuer on the HKEX.

 

CUSIP No.  07725L102   Page   5   of   10   Pages

 

 

1.

 

NAMES OF REPORTING PERSONS

 

Julian C. Baker 

2.

 

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

(a)
¨

(b)
¨

3.

 

SEC USE ONLY

 

4.

 

SOURCE OF FUNDS*

 

OO 

5.

 

CHECK
BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨

 

6.

 

CITIZENSHIP OR PLACE OF ORGANIZATION

 

United States 

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

7.

 

SOLE VOTING POWER:

 

154,315,490 (1) 

8.

 

 

SHARED VOTING POWER

  

9.

 

SOLE DISPOSITIVE POWER:

 

154,315,490 (1) 

10.

 

SHARED DISPOSITIVE POWER:

 

 

11.

 

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
PERSON:

 

154,315,490 (1) 

12.

 

CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
¨

 

13.

 

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(11)

 

13.0% (1)(2) 

14.

 

TYPE OF REPORTING PERSON*

 

IN, HC

 

(1) Includes 153,270,663 Ordinary Shares reported that
are beneficially owned through ADS, 18,564 Ordinary Shares received from vested RSU’s and 564,070 Ordinary Shares underlying
564,070 Share Options, Each ADS represents 13 Ordinary Shares of the Issuer.
(2) Based on 1,182,083,060 Ordinary Shares outstanding
at November 30, 2020 as reported by the Issuer on the HKEX on November 30, 2020.

 

CUSIP No.  07725L102   Page   6   of   10   Pages

 

 

1.

NAMES OF REPORTING PERSONS

 

FBB3 LLC 

2.

CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)

(a) ¨

(b) ¨

3.

SEC USE ONLY

 

4.

SOURCE OF FUNDS (See Instructions)

 

OO 

5.

CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
TO ITEMS 2(d) OR 2(e) ¨

 

6.

CITIZENSHIP OR PLACE OF ORGANIZATION    

 

Delaware

NUMBER
OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
7.

SOLE VOTING POWER

 

151,004 (1) 

8.

SHARED VOTING POWER

 

0

9.

SOLE DISPOSITIVE POWER

 

151,004 (1) 

10.

SHARED DISPOSITIVE POWER

 

11.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

151,004 (1)

12.

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES (See Instructions)

 

13.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

 

(2) 

14.

TYPE OF REPORTING PERSON (See Instructions)

 

OO 

 

(1) Includes 150,995 Ordinary Shares reported that are beneficially owned through ADS.
(2) The percentage is less than 0.1% based on 1,182,083,060 Ordinary Shares outstanding at November
30, 2020 as reported by the Issuer on the HKEX on November 30, 2020.

 

 

CUSIP No.  07725L102   Page   7   of   10   Pages

 

 

Amendment No. 8 to Schedule 13D

 

This Amendment No. 8 to Schedule 13D amends and supplements
the previously filed Schedules 13D filed by Baker Bros. Advisors LP (the “Adviser”), Baker Bros. Advisors (GP), LLC
(the “Adviser GP”), Julian C. Baker, Felix J. Baker and FBB3 LLC (“FBB3”) (collectively the “Reporting
Persons”). Except as supplemented herein, such statements, as heretofore amended and supplemented, remain in full force and
effect.

 

The Adviser GP is the sole general partner of the Adviser. Pursuant
to the management agreements, as amended, among the Adviser, Baker Brothers Life Sciences, L.P. (“Life Sciences”) and
667, L.P. (“667”, and together with Life Sciences, the “Funds”), and their respective general partners,
the Funds’ respective general partners relinquished to the Adviser all discretion and authority with respect to the investment
and voting power over securities held by the Funds, and thus the Adviser has complete and unlimited discretion and authority with
respect to the Funds’ investments and voting power over investments.

 

Item 3. Source and Amount of Funds or Other Consideration

 

The disclosure in Item 4 is incorporated herein by reference.

 

Item 4. Purpose of the Transaction.

 

Item 4 of Schedule 13D is supplemented and amended, as the case
may be, as follows:

 

On December 1, 2020, BeiGene, Ltd. (the “Issuer”)
and the Funds entered into an underwriting agreement (the “Underwriting Agreement”) with Goldman Sachs & Co. LLC
(the “Underwriter”), related to a public offering (the “Offering”) of 1,511,546 American Deposity Shares
(“ADS”) of the Issuer by the Funds as selling shareholders at a price to the public of $225.00 per ADS. Each ADS represents
13 Ordinary Shares. In addition, the Funds granted the Underwriter an option exercisable for 30 days from the date of the Underwriting
Agreement to purchase, at the public offering price less any underwriting discounts and commissions, up to an additional 151,154
ADS to cover overallotments, if any. The Offering closed on December 4, 2020.

 

Pursuant to the Offering, 667 and Life Sciences sold 125,513
and 1,386,033 ADS, respectively, at the offering price of $220.50 per share (net of underwriting discounts), totaling 1,511,546
shares in the aggregate.

 

The foregoing description of the Underwriting Agreement does
not purport to be complete and is qualified in its entirety by reference to the full text of the Underwriting Agreement, which is
incorporated by reference as Exhibit 99.1 hereto and is incorporated herein by reference.

 

The Funds hold securities of the Issuer for investment purposes.
The Reporting Persons or their affiliates may dispose of additional securities or purchase securities in varying amounts and at
varying times depending upon the Reporting Persons’ continuing assessments of pertinent factors, including the availability
of securities of the Issuer for purchase at particular price levels, the business prospects of the Issuer, other business investment
opportunities, economic conditions, stock market conditions, money market conditions, the attitudes and actions of the board of
directors of the Issuer (the “Board”) and management of the Issuer, the availability and nature of opportunities to
dispose of securities of the Issuer and other plans and requirements of the particular entities. The Reporting Persons may discuss
items of mutual interest with the Issuer’s management, other members of the Board and other investors, which could include
items in subparagraphs (a) through (j) of Item 4 Schedule 13D.

 

 

CUSIP No.  07725L102   Page   8   of   10   Pages

 

 

Depending upon their assessments of the above factors, the Reporting
Persons or their affiliates may change their present intentions as stated above and they may assess whether to make suggestions
to the management of the Issuer regarding financing, and whether to acquire additional securities of the Issuer (by means of open
market purchases, privately negotiated purchases, or otherwise) or to dispose of some or all of the securities of the Issuer under
their control.

 

Except as otherwise disclosed herein, at the present time, the
Reporting Persons do not have any plans or proposals with respect to any extraordinary corporate transaction involving the Issuer
including, without limitation, those matters described in subparagraphs (a) through (j) of Item 4 of Schedule 13D.

  

ITEM 5. Interest in Securities of the Issuer.

 

Item 5 of this Schedule 13D is hereby amended and restated as
follows:

 

(a) and (b) Items 7 through 11 and 13 of each of the cover pages
of this Amendment No. 8 are incorporated herein by reference.

 

Set
forth below is the aggregate number of Ordinary Shares directly held by the Funds, 153,270,663 of which are directly held by the
Funds through ADS, along with the percentage of the Issuer’s outstanding Ordinary Shares such holdings represent.
The
information set forth below is based on 1,182,083,060 Ordinary Shares outstanding at November 30, 2020 as reported by the Issuer
on the Hong Kong Exchange and Clearing Limited (“HKEX”) on November 30, 2020. Such percentage figures are calculated
in accordance with Rule 13d-3 under the Securities Exchange Act of 1934, as amended.

 

Name   Number of Ordinary Shares we own or have the right to acquire within 60 days     Percent of Class Outstanding  
667, L.P.     12,727,060       1.1 %
Baker Brothers Life Sciences, L.P.     140,543,649       11.9 %
Total     153,270,709       13.0 %

  

Michael Goller and Ranjeev Krishana, full-time employees of
the Adviser, have served on the Board since April 21, 2015 and October 7, 2014, respectively. Prior to serving on the Board, Michael
Goller was a Board observer. Michael Goller and Ranjeev Krishana currently serve on the Board as representatives of the Funds.
Michael Goller and Ranjeev Krishana each hold 282,035 options to purchase Ordinary Shares (“Share Options”) received
in connection with their service on the Board which vest within 60 days from the date of this Amendment No. 8. Michael Goller and
Ranjeev Krishana each hold 9,282 Ordinary Shares received from vested restricted stock units (“RSU’s”) in connection
with their service on the Board. Additionally, Michael Goller and Ranjeev Krishana each hold 45,383 Share Options (“2020
Share Options”) in connection with their service on the Board. The 2020 Share Options are exercisable at $13.42 per Ordinary
Share and vest on the earlier of the first anniversary of the date of grant or the date of the next annual meeting of shareholders.
The 2020 Stock Options expire June 16, 2030.The policy of the Funds and the Adviser does not permit managing members of the Adviser
GP or full-time employees of the Adviser to receive compensation for serving as directors of the Issuer, and the Funds are instead
entitled to the pecuniary interest in any compensation received for their service.

 

The Adviser GP, Felix J. Baker and Julian C. Baker as managing
members of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the
Funds.

 

Julian C. Baker and Felix J. Baker are also the sole managers
of FBB3 and by policy they do not transact in or vote the securities of the Issuer held by FBB3.

 

  

CUSIP No.  07725L102   Page   9   of   10   Pages

 

 

(c) The disclosure in Item 4 and elsewhere in this Item 5 is
incorporated herein by reference. Except as disclosed herein, none of the Reporting Persons or their affiliates has effected any
other transactions in securities of the Issuer during the past 60 days.

 

(d) Certain securities of the Issuer are held directly by 667,
a limited partnership the sole general partner of which is Baker Biotech Capital, L.P., a limited partnership the sole general
partner of which is Baker Biotech Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the managing members of Baker Biotech
Capital (GP), LLC.

 

Certain securities of the Issuer are held directly by Life Sciences,
a limited partnership the sole general partner of which is Baker Brothers Life Sciences Capital, L.P., a limited partnership the
sole general partner of which is Baker Brothers Life Sciences Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the managing
members of Baker Brothers Life Sciences Capital (GP), LLC.

 

(e) Not applicable.

 

Item
6.
Contracts,
Arrangements, Understandings or Relationships with Respect to Securities of the Issuer

   

Item 6 of this Schedule 13D is hereby supplemented and amended,
as the case may be, as follows:

 

The disclosure in Item 4 is incorporated herein by reference.

 

The Underwriting Agreement is incorporated by reference as Exhibit
99.1 hereto and is incorporated herein by reference.

 

On December 1, 2020, the Issuer and the Funds along with other
investors entered into Amendment No.1 (the “Amendment”) to the registration rights agreement that was previously disclosed
and entered into on November 16, 2016 (“Registration Rights Agreement”). Pursuant to the Amendment, effective December
31, 2020, the Issuer’s registration obligations under the Registration Rights Agreement will continue in effect for up to another
three years, until December 31, 2023.

 

The foregoing description of the Amendment does not purport
to be complete and is qualified in its entirety by reference to the full text of the Amendment, which is incorporated by reference
as Exhibit 99.2 hereto and is incorporated herein by reference.

 

In connection with the offering the Funds each entered into
a lock-up agreement with the underwriter (“Lock-up Agreement”) dated December 1, 2020 pursuant to which the Funds
agreed that from December 1, 2020 until 60 days after the public offering date set forth in the final prospectus for the Offering,
the Funds agreed not to offer, sell, contract to sell, pledge, grant any option to purchase, purchase any option or contract to
sell, make any short sale or otherwise dispose of any ADSs or Ordinary Shares or any securities of the Issuer that are substantially
similar to the ADSs or Ordinary Shares of the Issuer, or any options or warrants to purchase any ADSs or Ordinary Shares of the
Issuer, or any securities convertible into, exchangeable for or that represent the right to receive ADSs or Ordinary Shares of
the Issuer, whether now owned or hereinafter acquired, owned directly by the undersigned (including holding as a custodian) or
with respect to which the undersigned has beneficial ownership within the rules and regulations of the SEC. The foregoing description
of the Lock Up Agreements does not purport to be complete and is qualified in its entirety by reference
to the full text of the Amendment, which is incorporated by reference as Exhibit 99.3 and Exhibit 99.4 hereto and is incorporated
herein by reference.

 

Item 7. Materials to be filed as Exhibits

 

 

Exhibit Description
99.1 Underwriting Agreement, dated December 1, 2020, by and between the Issuer and the Funds and Goldman Sachs & Co.  as the representative of the several underwriters listed on Schedule I thereto (incorporated by reference to Exhibit 1.1 of the Form 8-K filed by the Issuer with the SEC on December 2, 2020).
99.2 Amendment No. 1 To Registration Rights Agreement, dated December 1, 2020, by and among the Issuer, the Funds and other investors. (incorporated by reference to Exhibit 10.1 to the Issuer’s Current Report on Form 8-K, filed with the SEC on December 2, 2020).
99.3 Selling Shareholder Lock-Up Agreement, dated December 1, 2020, by and among 667 and Goldman Sachs & Co.  as the representative of the several underwriters listed on Schedule I thereto..
99.4 Selling Shareholder Lock-Up Agreement, dated December 1, 2020, by and among Life Sciences and Goldman Sachs & Co.  as the representative of the several underwriters listed on Schedule I thereto..

  

 

CUSIP No.  07725L102   Page   10   of   10   Pages

 

 

SIGNATURE

 

After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true, complete and correct.

 

December 4, 2020

 

 

BAKER BROS. ADVISORS LP

 

By: Baker Bros. Advisors (GP) LLC, its general partner

     
  By: /s/ Scott L. Lessing
    Name: Scott L. Lessing
Title: President

 

  BAKER BROS. ADVISORS (GP) LLC
     
  By: /s/ Scott L. Lessing
    Name: Scott L. Lessing
Title: President

 

  /s/ Julian C. Baker
  Julian C. Baker
   
  /s/ Felix J. Baker
  Felix J. Baker

 

  FBB3
LLC
   
  By: /s/
Julian C. Baker
    Name: Julian C. Baker
Title:   Manager

  

 

 

Exhibit 99.3

 

Selling Shareholder
Lock-Up Agreement

December 1, 2020

 

 

Goldman
Sachs & Co. LLC

As
representative of the several Underwriters

named
in Schedule I to the Underwriting Agreement

 

c/o Goldman Sachs & Co. LLC 200 West Street

New
York, New York 10282

  

Re: BeiGene, Ltd. – Lock-Up Agreement

 

Ladies
and Gentlemen:

 

The undersigned
understands that you, as representative (the “Representative”), propose to enter into an underwriting agreement (the
“Underwriting Agreement”) on behalf of the several underwriters named in Schedule I to such agreement (collectively,
the “Underwriters”), with BeiGene, Ltd., a Cayman Islands exempted company (the “Company”), and certain
holders (the “Selling Shareholders”) of the Company’s American Depositary Shares (the “ADSs”) representing
ordinary shares of the Company, par value US$0.0001 per share (the “Ordinary Shares”), providing for a public offering
(the “Public Offering”) of ADSs by the Selling Shareholders, pursuant to a Registration Statement on Form S-3 (File
No. 333-238182) (the “Registration Statement”) and a Registration Statement on Form F-6 (File No. 333-209044) filed
with the U.S. Securities and Exchange Commission (the “SEC”).

 

In consideration
of the agreement by the Underwriters to offer and sell the ADSs, and of other good and valuable consideration the receipt and sufficiency
of which is hereby acknowledged, the undersigned agrees that, during the period specified in the following paragraph (the “Lock-Up
Period”), the undersigned will not offer, sell, contract to sell, pledge, grant any option to purchase, purchase any option
or contract to sell, make any short sale or otherwise dispose of any ADSs or Ordinary Shares or any securities of the Company that
are substantially similar to the ADSs or Ordinary Shares of the Company, or any options or warrants to purchase any ADSs or Ordinary
Shares of the Company, or any securities convertible into, exchangeable for or that represent the right to receive ADSs or Ordinary
Shares of the Company, whether now owned or hereinafter acquired, owned directly by the undersigned (including holding as a custodian)
or with respect to which the undersigned has beneficial ownership within the rules and regulations of the SEC (collectively the
“Undersigned’s Shares”). The foregoing restriction is expressly agreed to preclude the undersigned from engaging in
any hedging or other transaction which is designed to or which reasonably could be expected to lead to or result in a sale or disposition
of the Undersigned’s Shares even if such Undersigned’s Shares would be disposed of by someone other than the undersigned.
Such prohibited hedging or other transactions would include
without limitation any short sale or any purchase, sale or grant of any right (including without limitation any put or call option)
with respect to any of the Undersigned’s Shares or with respect to any security that includes, relates to, or derives any
significant part of its value from such Undersigned’s Shares.

 

 

The Lock-Up
Period will commence on the date of this letter agreement (the “Lock-Up Agreement”) and continue for 60 days after
the public offering date set forth on the final prospectus used to sell the ADSs (the “Public Offering Date”).

 

Notwithstanding
the foregoing, the undersigned may transfer the Undersigned’s Shares:

 

(i) pursuant to transactions relating to Ordinary Shares, ADSs or other securities acquired in open market transactions after
the Public Offering Date,

 

(ii)
as a bona fide gift or gifts,

 

(iii) 
pursuant to a bona fide third-party tender offer, merger, consolidation or other similar transaction occurring after
the completion of the Public Offering, in each case made to all holders of Ordinary Shares, including in the form of ADSs, involving
a Change of Control (as defined below), provided that (x) in the event that the tender offer, merger, consolidation or other
such transaction is not completed, the Undersigned’s Shares shall remain subject to the terms of this Lock-Up Agreement and
(y) no such transfer of Ordinary Shares, ADS or any such warrant or other security shall be permitted pursuant to this clause (vii)
if such bona fide third-party tender offer, merger, consolidation or other similar transaction is not approved by the board
of directors of the Company, unless either (A) such transfer is required pursuant to mandatory take- over or squeeze-out provisions
under applicable law or (B) the failure to so transfer such Undersigned’s Shares would result in such Undersigned’s
Shares being extinguished without value being received by the undersigned,

 

(iv) by operation of law, such as pursuant to an order of a court or regulatory agency of competent jurisdiction, or

 

(v) 
with the prior written consent of the Representative on behalf of the Underwriters.

 

Notwithstanding
the foregoing, nothing in this Lock-Up Agreement shall prohibit the exercise of any option, warrant or other rights to acquire
the Company’s Ordinary Shares, ADSs or other securities, the settlement of any share-settled share appreciation rights,
restricted shares or restricted share units or the conversion of any convertible security into Ordinary Shares or ADSs, in each
case pursuant to agreements or arrangements described in the Registration Statement, provided that the underlying Ordinary
Shares, ADSs or other securities remain subject to this Lock-Up Agreement and provided, further that no filing under
the Exchange Act nor any other public filing or disclosure of such transfer by or on behalf of the undersigned shall be required
or voluntarily made during the Lock-Up Period. In addition, with respect to clauses (i) and (ii) above, it shall be a condition
to such transfer that no filing under the Exchange Act nor any other public filing or disclosure of such transfer by or on behalf
of the undersigned shall be required or voluntarily made during the Lock-Up Period and, with respect to clauses (ii) and (iii),
prior to such transfer or distribution, the transferee, donee, trustee or distributee agrees to be bound in writing by the restrictions
set forth herein.

 

 

In addition,
notwithstanding the foregoing, if the undersigned is a corporation, partnership, limited liability company, trust or other business
entity, the undersigned may transfer the Undersigned’s Shares (x) to another corporation, partnership, limited liability
company, trust or other affiliate (as defined in Rule 405 promulgated under the Securities Act of 1933, as amended) of the undersigned
(including, for the avoidance of doubt, a fund managed by the same manager or managing member or general partner or management
company or by an entity controlling, controlled by, or under common control with such manager or managing member or general partner
or management company as the undersigned or who shares a common investment advisor with the undersigned) or (y) as part of a distribution
without consideration by the undersigned to its stockholders, partners, members or other equity holders; provided, however,
that in any such case, it shall be a condition to the transfer that the transferee execute an agreement stating that the transferee
is receiving and holding such Undersigned’s Shares subject to the provisions of this Lock-Up Agreement and there shall be
no further transfer of such Undersigned’s Shares except in accordance with this Lock-Up Agreement, and provided, further
that any such transfer shall not involve a disposition for value. Furthermore, nothing in this Lock-Up Agreement shall be deemed
to prevent the undersigned from establishing any contract, instruction or plan (a “Plan”) pursuant to Rule 10b5-1 under
the Exchange Act for the transfer of ADSs or Ordinary Shares; provided that (x) such Plan does not provide for the transfer
of ADSs or Ordinary Shares during the Lock-Up Period and (y) no public announcement or filing under the Exchange Act regarding
the establishment of such Plan shall be required of or voluntarily made by or on behalf of the undersigned or the Company. In addition,
notwithstanding the forgoing, nothing in this Lock-Up Agreement shall be deemed to prevent the registration of the offering and
sale of the Company’s securities as contemplated by the Underwriting Agreement and the sale of the Undersigned’s Shares
to the Underwriters in the Public Offering pursuant to the Underwriting Agreement.

 

The undersigned
now has, and, except as contemplated by the above, for the duration of this Lock-Up Agreement will have, good and marketable title
to the Undersigned’s Shares, free and clear of all liens, encumbrances, and claims whatsoever. The undersigned also agrees
and consents to the entry of stop transfer instructions with the Company’s transfer agent and registrar and the depositary
for the ADSs against the transfer of the Undersigned’s Shares except in compliance with the foregoing restrictions.

 

For purposes
of this Lock-Up Agreement, “Change of Control” shall mean the transfer (whether by tender offer, merger, consolidation
or other similar transaction), in one transaction or a series of related transactions, to a person or group of affiliated persons
(other than an Underwriter pursuant to the Public Offering), of the Company’s voting securities if, after such transfer,
such person or group of affiliated persons would hold more than 50% of the outstanding voting securities
of the Company (or the surviving entity).

 

 

This Lock-Up Agreement may be
delivered via facsimile, electronic mail (including pdf or any electronic signature complying with the U.S. federal ESIGN Act of
2000, e.g., www.docusign.com or www.echosign.com) or other transmission method and any counterpart so delivered shall be deemed
to have been duly and validly delivered and be valid and effective for all purposes.

 

The undersigned
acknowledges and agrees that the Underwriters have not provided any recommendation or investment advice nor have the Underwriters
solicited any action from the undersigned with respect to the Public Offering of the securities and the undersigned has consulted
their own legal, accounting, financial, regulatory and tax advisors to the extent deemed appropriate.

 

The undersigned
understands that the Company, the Selling Shareholders and the Underwriters are relying upon this Lock-Up Agreement in proceeding
toward consummation of the Public Offering. The undersigned further understands that this Lock-Up Agreement is irrevocable and
shall be binding upon the undersigned’s heirs, legal representatives, successors, and assigns.

 

This Lock-Up
Agreement (and for the avoidance of doubt, the Lock-Up Period described herein) and related restrictions shall automatically terminate
upon the earliest to occur, if any, of (i) the Representative, on behalf of the Underwriters, on the one hand, or the Selling Shareholders,
on the other hand, advising the other in writing prior to the execution of the Underwriting Agreement that such party has determined
not to proceed with the Public Offering contemplated by the Underwriting Agreement and (ii) the termination of the Underwriting
Agreement (other than the provisions thereof which survive termination) prior to payment for and delivery of the ADSs or Ordinary
Shares.

 

 

[Signature Page Follows]

 

 

Very
truly yours,

 

 

667, L.P.

 

By: BAKER BROS. ADVISORS LP, management
company and investment adviser to 667, L.P., pursuant to authority granted to it by Baker Biotech Capital, L.P., general
partner to 667, L.P., and not as the general partner.

 

By: /s/ Scott L. Lessing  
Scott L. Lessing  
President  

  

 

 

 

 

Signature Page to Selling Shareholder Lock-Up
Agreement

 

 

 

Exhibit 99.4

 

Selling Shareholder
Lock-Up Agreement

December 1, 2020

 

 

Goldman
Sachs & Co. LLC

As
representative of the several Underwriters

named
in Schedule I to the Underwriting Agreement

 

c/o Goldman Sachs & Co. LLC 200 West Street

New
York, New York 10282

 

Re: BeiGene, Ltd. – Lock-Up Agreement

 

Ladies
and Gentlemen:

 

The
undersigned understands that you, as representative (the “Representative”), propose to enter into an underwriting
agreement (the “Underwriting Agreement”) on behalf of the several underwriters named in Schedule I to such
agreement (collectively, the “Underwriters”), with BeiGene, Ltd., a Cayman Islands exempted company (the “Company”),
and certain holders (the “Selling Shareholders”) of the Company’s American Depositary Shares (the “ADSs”)
representing ordinary shares of the Company, par value US$0.0001 per share (the “Ordinary Shares”), providing for
a public offering (the “Public Offering”) of ADSs by the Selling Shareholders, pursuant to a Registration Statement
on Form S-3 (File No. 333-238182) (the “Registration Statement”) and a Registration Statement on Form F-6 (File No.
333-209044) filed with the U.S. Securities and Exchange Commission (the “SEC”).

 

In consideration
of the agreement by the Underwriters to offer and sell the ADSs, and of other good and valuable consideration the receipt and
sufficiency of which is hereby acknowledged, the undersigned agrees that, during the period specified in the following paragraph
(the “Lock-Up Period”), the undersigned will not offer, sell, contract to sell, pledge, grant any option to purchase,
purchase any option or contract to sell, make any short sale or otherwise dispose of any ADSs or Ordinary Shares or any securities
of the Company that are substantially similar to the ADSs or Ordinary Shares of the Company, or any options or warrants to purchase
any ADSs or Ordinary Shares of the Company, or any securities convertible into, exchangeable for or that represent the right to
receive ADSs or Ordinary Shares of the Company, whether now owned or hereinafter acquired, owned directly by the undersigned (including
holding as a custodian) or with respect to which the undersigned has beneficial ownership within the rules and regulations of
the SEC (collectively the “Undersigned’s Shares”). The foregoing restriction is expressly agreed to preclude the undersigned
from engaging in any hedging or other transaction which is designed to or which reasonably could be expected to lead to or result
in a sale or disposition of the Undersigned’s Shares even if such Undersigned’s Shares would be disposed of by someone other
than the undersigned. Such prohibited hedging or other transactions would include without limitation any short sale or any purchase,
sale or grant of any right (including without limitation any put or call option) with respect to any of the Undersigned’s
Shares or with respect to any security that includes, relates to, or derives any significant part of its value from such Undersigned’s
Shares. 

 

 

The Lock-Up
Period will commence on the date of this letter agreement (the “Lock-Up Agreement”) and continue for 60 days after
the public offering date set forth on the final prospectus used to sell the ADSs (the “Public Offering Date”).

 

Notwithstanding
the foregoing, the undersigned may transfer the Undersigned’s Shares:

 

(i) 
pursuant to transactions relating to Ordinary Shares, ADSs or other securities acquired in open market transactions after
the Public Offering Date,

 

(ii)
as a bona fide gift or gifts,

 

(iii) pursuant to a bona fide third-party tender offer, merger, consolidation or other similar transaction occurring after
the completion of the Public Offering, in each case made to all holders of Ordinary Shares, including in the form of ADSs, involving
a Change of Control (as defined below), provided that (x) in the event that the tender offer, merger, consolidation or other
such transaction is not completed, the Undersigned’s Shares shall remain subject to the terms of this Lock-Up Agreement and
(y) no such transfer of Ordinary Shares, ADS or any such warrant or other security shall be permitted pursuant to this clause (vii)
if such bona fide third-party tender offer, merger, consolidation or other similar transaction is not approved by the board
of directors of the Company, unless either (A) such transfer is required pursuant to mandatory take- over or squeeze-out provisions
under applicable law or (B) the failure to so transfer such Undersigned’s Shares would result in such Undersigned’s
Shares being extinguished without value being received by the undersigned,

 

(iv) by operation of law, such as pursuant to an order of a court or regulatory agency of competent jurisdiction, or

 

(v) with the prior written consent of the Representative on behalf of the Underwriters.

 

Notwithstanding
the foregoing, nothing in this Lock-Up Agreement shall prohibit the exercise of any option, warrant or other rights to acquire
the Company’s Ordinary Shares, ADSs or other securities, the settlement of any share-settled share appreciation rights,
restricted shares or restricted share units or the conversion of any convertible security into Ordinary Shares or ADSs, in each
case pursuant to agreements or arrangements described in the Registration Statement, provided that the underlying Ordinary
Shares, ADSs or other securities remain subject to this Lock-Up Agreement and provided, further that no filing under
the Exchange Act nor any other public filing or disclosure of such transfer by or on behalf of the undersigned shall be required
or voluntarily made during the Lock-Up Period. In addition, with respect to clauses (i) and (ii) above, it shall be a condition
to such transfer that no filing under the Exchange Act nor any other public filing or disclosure of such transfer by or on behalf
of the undersigned shall be required or voluntarily made during the Lock-Up Period and, with respect to clauses (ii) and (iii),
prior to such transfer or distribution, the transferee, donee, trustee or distributee agrees to be bound in writing by the restrictions
set forth herein.

 

 

In addition,
notwithstanding the foregoing, if the undersigned is a corporation, partnership, limited liability company, trust or other business
entity, the undersigned may transfer the Undersigned’s Shares (x) to another corporation, partnership, limited liability
company, trust or other affiliate (as defined in Rule 405 promulgated under the Securities Act of 1933, as amended) of the undersigned
(including, for the avoidance of doubt, a fund managed by the same manager or managing member or general partner or management
company or by an entity controlling, controlled by, or under common control with such manager or managing member or general partner
or management company as the undersigned or who shares a common investment advisor with the undersigned) or (y) as part of a distribution
without consideration by the undersigned to its stockholders, partners, members or other equity holders; provided, however,
that in any such case, it shall be a condition to the transfer that the transferee execute an agreement stating that the transferee
is receiving and holding such Undersigned’s Shares subject to the provisions of this Lock-Up Agreement and there shall be
no further transfer of such Undersigned’s Shares except in accordance with this Lock-Up Agreement, and provided, further
that any such transfer shall not involve a disposition for value. Furthermore, nothing in this Lock-Up Agreement shall be deemed
to prevent the undersigned from establishing any contract, instruction or plan (a “Plan”) pursuant to Rule 10b5-1 under
the Exchange Act for the transfer of ADSs or Ordinary Shares; provided that (x) such Plan does not provide for the transfer
of ADSs or Ordinary Shares during the Lock-Up Period and (y) no public announcement or filing under the Exchange Act regarding
the establishment of such Plan shall be required of or voluntarily made by or on behalf of the undersigned or the Company. In addition,
notwithstanding the forgoing, nothing in this Lock-Up Agreement shall be deemed to prevent the registration of the offering and
sale of the Company’s securities as contemplated by the Underwriting Agreement and the sale of the Undersigned’s Shares
to the Underwriters in the Public Offering pursuant to the Underwriting Agreement.

 

The undersigned
now has, and, except as contemplated by the above, for the duration of this Lock-Up Agreement will have, good and marketable title
to the Undersigned’s Shares, free and clear of all liens, encumbrances, and claims whatsoever. The undersigned also agrees
and consents to the entry of stop transfer instructions with the Company’s transfer agent and registrar and the depositary
for the ADSs against the transfer of the Undersigned’s Shares except in compliance with the foregoing restrictions.

 

For purposes
of this Lock-Up Agreement, “Change of Control” shall mean the transfer (whether by tender offer, merger, consolidation
or other similar transaction), in one transaction or a series of related transactions, to a person or group of affiliated persons
(other than an Underwriter pursuant to the Public Offering), of the Company’s voting securities if, after such transfer,
such person or group of affiliated persons would hold more than 50% of the outstanding voting securities
of the Company (or the surviving entity).

 

 

This Lock-Up Agreement may be
delivered via facsimile, electronic mail (including pdf or any electronic signature complying with the U.S. federal ESIGN Act of
2000, e.g., www.docusign.com or www.echosign.com) or other transmission method and any counterpart so delivered shall be deemed
to have been duly and validly delivered and be valid and effective for all purposes.

 

The undersigned
acknowledges and agrees that the Underwriters have not provided any recommendation or investment advice nor have the Underwriters
solicited any action from the undersigned with respect to the Public Offering of the securities and the undersigned has consulted
their own legal, accounting, financial, regulatory and tax advisors to the extent deemed appropriate.

 

The undersigned
understands that the Company, the Selling Shareholders and the Underwriters are relying upon this Lock-Up Agreement in proceeding
toward consummation of the Public Offering. The undersigned further understands that this Lock-Up Agreement is irrevocable and
shall be binding upon the undersigned’s heirs, legal representatives, successors, and assigns.

 

This Lock-Up
Agreement (and for the avoidance of doubt, the Lock-Up Period described herein) and related restrictions shall automatically terminate
upon the earliest to occur, if any, of (i) the Representative, on behalf of the Underwriters, on the one hand, or the Selling Shareholders,
on the other hand, advising the other in writing prior to the execution of the Underwriting Agreement that such party has determined
not to proceed with the Public Offering contemplated by the Underwriting Agreement and (ii) the termination of the Underwriting
Agreement (other than the provisions thereof which survive termination) prior to payment for and delivery of the ADSs or Ordinary
Shares.

 

 

[Signature Page Follows]

 

 

Very
truly yours,

  

 

BAKER BROTHERS LIFE SCIENCES, L.P.

 

By: BAKER BROS. ADVISORS LP, management company and investment
adviser to Baker Brothers Life Sciences, L.P., pursuant to authority granted to it by Baker Brothers Life Sciences Capital,
L.P., general partner to Baker Brothers Life Sciences, L.P., and not as the general partner.

 

By: /s/ Scott L. Lessing  
Scott L. Lessing  
President  

 

 

 

 

 

 

Signature Page to Selling Shareholder Lock-Up
Agreement

 

 



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